MS Awareness Week

In this study, induced neural stem cells (iNSCs) were generated to expose a PMS-specific interferon signalling gene signature and lipid metabolism.

MS Awareness Week

This week is Multiple Sclerosis Awareness Week, so we are going to dive into a recent paper which studies the complexities of progressive multiple sclerosis (PMS). In this study, induced neural stem cells (iNSCs) were generated from patient-derived fibroblasts, preserving their epigenome to expose a PMS-specific interferon signalling gene signature and lipid metabolism.

This work has uncovered a novel cellular axis which may be at the root of the neurodegenerative mechanism of PMS, indicating potential therapeutic targets for future research.

Please read the paper leave a rating and join the conversation!

Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis